Lactate, Pyruvate, Acetoacetate and 3-Hydroxybutyrate Abstract Lactate, pyruvate, acetoacetate, and 3-hydroxybutyrate are intermediary metabolites that normally occur in blood and all have an essential role in energy production Their blood accumulation is a frequent cause of metabolic acidosis for children
Lactate, Pyruvate, Acetoacetate, and 3-Hydroxybutyrate Lactate accumulation in blood higher than 5 mmol L leads to lactic acidosis Hyperlactatemia can be observed in ischemic conditions or in many inherited metabolic diseases (pyruvate dehydrogenase deficiency, pyruvate carboxylase deficiency, etc )
Lactate, Pyruvate, Acetoacetate, and 3-Hydroxybutyrate Pyruvate is transformed to lactate by lactate dehydrogenase (LDH) under anaerobic conditions Ketone bodies (KBs) circulate in the blood as 3-hydroxybutyrate (3OHB) and acetoacetate (ACAC)
Beta-Hydroxybutyrate, Serum - Duke University Hospital Beta-hydroxybutyrate (BHB) is 1 of 3 sources of ketone bodies Its relative proportion in the blood (78%) is greater than the other 2 ketone bodies, acetoacetate (20%) and acetone (2%)
22 - Laboratory Diagnosis of Inborn Errors of Metabolism This chapter focuses predominantly on the laboratory diagnosis of three major groups of metabolic diseases: organic acidurias, congenital lactic acidemias, and disorders of fatty acid transport and oxidation Aspects of urea cycle defects and amino acid disorders are covered to a lesser extent
Lactate, Pyruvate, Acetoacetate and 3-Hydroxybutyrate Lactate, pyruvate, acetoacetate, and 3-hydroxybutyrate are intermediary metabolites that normally occur in blood and all have an essential role in energy production Their blood accumulation is